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How Long Does Promethazine Stay in Your System?

Street names for promethazine include purple drank, lean, and dirty Sprite

Promethazine is a prescription medication used to treat allergies, motion sickness, nausea, vomiting, and difficulty sleeping. It belongs to a class of drugs called phenothiazines. While it’s safe and effective when used as prescribed, it also has the potential for misuse and addiction. If you or a loved one is struggling with promethazine use, it’s important to understand how this drug works and how long it remains in the body. Swift River, a leading drug and alcohol addiction treatment center in Western Massachusetts, is here to help.

What Is Promethazine and How Does It Work?

Promethazine is an antihistamine that works by blocking histamine, a natural substance produced by the body during an allergic reaction. This helps relieve symptoms such as itching, runny nose, watery eyes, and sneezing. Promethazine also has sedative effects. It works on the brain to decrease nausea, vomiting, and motion sickness. These calming properties are why some people misuse it for its euphoric and relaxing high. The drug comes in tablet, syrup, and liquid form. Street names include purple drank, lean, and dirty Sprite.

How Long Does Promethazine Stay in Your System?

Several factors affect how long promethazine remains in your system:

  • Metabolism: People with faster metabolisms clear the drug more quickly.
  • Dosage: Higher doses take longer to metabolize.
  • Frequency of use: Regular, long-term use causes the drug to accumulate in your body.
  • Age: Older adults tend to clear promethazine more slowly.
  • Liver and kidney function: These organs filter the drug from your body. Any impairment can slow removal.

In general, promethazine has a half-life of 16-19 hours. This means it takes that amount of time for half a dose to leave your system.

Drug tests can detect promethazine in your body for a certain period after last use:

  • Urine: up to 2-3 days
  • Blood: up to 24 hours
  • Saliva: up to 2-3 days
  • Hair: up to 90 days
Promethazine is a prescription medication used to treat allergies, motion sickness, nausea, vomiting, and difficulty sleeping
Promethazine is a prescription medication used to treat allergies, motion sickness, nausea, vomiting, and difficulty sleeping

The Risks of Promethazine Misuse

While promethazine is safe when used properly, taking it in ways not prescribed by a doctor can be dangerous. Misusing can cause:

  • Drowsiness and dizziness
  • Slowed breathing
  • Blurred vision
  • Confusion and disorientation
  • Chemical dependence and addiction

Promethazine is often combined with opioids, alcohol, and other illicit drugs to intensify their effects. This greatly increases the risk of severe complications like respiratory depression, overdose, and death.

Swift River: Compassionate, Evidence-Based Addiction Treatment

If you’re struggling with addiction, know that recovery is possible. At Swift River, we provide compassionate, evidence-based treatment for substance use disorders and co-occurring mental health conditions.

Our experienced staff will work with you to develop an individualized treatment plan that fits your unique needs and goals. Through a combination of medical detox, counseling, and holistic therapies, you’ll gain the tools and support to overcome addiction and build a healthy, drug-free life.

Don’t wait another day to get the help you need. Call Swift River at 888-451-5895 to learn more about our programs and take the first step toward lasting recovery.

Contact Swift River Now

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